Production of Macrophage Inflammatory Protein 3α (MIP-3α) (CCL20) and MIP-3β (CCL19) by Human Peripheral Blood Neutrophils in Response to Microbial Pathogens

Author:

Akahoshi Tohru1,Sasahara Takeshi2,Namai Rie3,Matsui Toshimichi3,Watabe Hiroyuki3,Kitasato Hidero2,Inoue Matsuhisa2,Kondo Hirobumi3

Affiliation:

1. Departments of Laboratory Medicine

2. Microbiology

3. Internal Medicine, Kitasato University School of Medicine, Kanagawa, Japan

Abstract

ABSTRACT Effects of bacterial pathogens on the production of macrophage inflammatory protein 3α (MIP-3α) and MIP-3β from human peripheral blood neutrophils were investigated. Neutrophils produced both chemokines by coincubation with either gram-positive or gram-negative bacteria. Neutrophils may initiate antigen-specific immune responses through the release of these chemokines that are capable of promoting selective recruitment of dendritic cells and T-cell subsets.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

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