Feasibility of an HA2 Domain-Based Periodontitis Vaccine-Reference-Cited by-同舟云学术

Feasibility of an HA2 Domain-Based Periodontitis Vaccine

Published:2003-01 Issue:1 Volume:71 Page:562-566
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

DeCarlo A. A.¹,Huang Y.²,Collyer C. A.³,Langley D. B.³,Katz J.²

Affiliation:

1. Vaccine Research Division, Agenta Biotechnologies, Birmingham, Alabama 35253

2. Department of Oral Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294

3. Department of Biochemistry, University of Sydney, New South Wales 2006, Australia

Abstract

ABSTRACT In a rat periodontitis model, preinoculation with the Porphyromonas gingivalis HA2 binding domain for hemoglobin provided protection from disease. Protection was associated with induced anti-HA2 immunoglobulin G (IgG) humoral antibodies. The IgG subclass ratios suggested that relatively lower Th2/Th1-driven responses were directly associated with protection when rHA2 was administered in saline.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.71.1.562-566.2003

Reference37 articles.

1. Arbes, S. J., Jr., G. D. Slade, and J. D. Beck. 1999. Association between extent of periodontal attachment loss and self-reported history of heart attack: an analysis of NHANES III data. J. Dent. Res.78:1777-1782.

2. Bazin, H., J. Rousseaux, R. Rousseaux-Prevost, B. Platteau, P. Querinjean, J. M. Malache, and T. Delaunay. 1990. Rat immunoglobulins, p. 5-42. In H. Bazin (ed.), Rat hybridomas and rat monoclonal antibodies. CRC Press, Inc., Boca Raton, Fla.

3. Roles of porphyrins and host iron transport proteins in regulation of growth of Porphyromonas gingivalis W50

4. Calkins, C. C., K. Platt, J. Potempa, and J. Travis. 1998. Inactivation of tumor necrosis factor-alpha by proteinases (gingipains) from the periodontal pathogen, Porphyromonas gingivalis: implications of immune evasion. J. Biol. Chem.273:6611-6614.

5. Chen, H. A., B. D. Johnson, T. J. Sims, R. P. Darveau, B. J. Moncla, C. W. Whitney, D. Engel, and R. C. Page. 1991. Humoral immune responses to Porphyromonas gingivalis before and following therapy in rapidly progressive periodontitis patients. J. Periodontol.62:781-791.

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