Biosynthesis of Ubiquinone in Escherichia coli K-12: Biochemical and Genetic Characterization of a Mutant Unable to Convert Chorismate into 4-Hydroxybenzoate-Reference-Cited by-同舟云学术

Biosynthesis of Ubiquinone in Escherichia coli K-12: Biochemical and Genetic Characterization of a Mutant Unable to Convert Chorismate into 4-Hydroxybenzoate

Published:1974-04 Issue:1 Volume:118 Page:41-45
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Lawrence J.¹,Cox G. B.¹,Gibson F.¹

Affiliation:

1. Department of Biochemistry, John Curtin School of Medical Research, The Institute of Advanced Studies, Australian National University, Canberra, A.C.T., Australia

Abstract

A mutant strain of Escherichia coli unable to carry out the first specific reaction of ubiquinone biosynthesis, that is the conversion of chorismate into 4-hydroxybenzoate, has been isolated. The gene concerned maps at about minute 79 on the E. coli chromosome and has been designated ubiC . This gene is probably the structural gene for chorismate lyase since cell extracts from a transductant strain carrying the ubiC437 mutant allele are unable to convert chorismate into 4-hydroxybenzoate and growing cells of the mutant do not form appreciable quantities of ubiquinone unless 4-hydroxybenzoate is added to the growth medium.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jb.118.1.41-45.1974

Reference25 articles.

1. The role of shikimic acid in the biosynthesis of vitamin K2;Cox G. B.;Biochem. J.,1966

2. Mutant strains of Escherichia coli K-12 unable to form ubiquinone;Cox G. B.;J. Bacteriol.,1968

3. Biosynthesis of ubiquinone in Escherichia coli K-12: location of genes affecting the metabolism of 3-octapreny1-4-hydroxybenzoic acid and 2-octaprenylphenol;Cox G. B.;J. Bacteriol.,1969

4. Inhibition of Escherichia coli by p-aminobenzoic acid and its reversal by p-hydroxybenzoic acid;Davis B. D.;J. Exp. Med.,1951

5. Chorismic acid;Gibson F.;Biochem. Prep.,1968

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