Acquisition of the L452R Mutation in the ACE2-Binding Interface of Spike Protein Triggers Recent Massive Expansion of SARS-CoV-2 Variants-Reference-Cited by-同舟云学术

Acquisition of the L452R Mutation in the ACE2-Binding Interface of Spike Protein Triggers Recent Massive Expansion of SARS-CoV-2 Variants

Published:2021-10-19 Issue:11 Volume:59 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Tchesnokova Veronika¹²,Kulasekara Hemantha³,Larson Lydia¹,Bowers Victoria⁴,Rechkina Elena²,Kisiela Dagmara¹,Sledneva Yulia²,Choudhury Debarati²,Maslova Iryna²,Deng Kai³,Kutumbaka Kirthi³,Geng Hao³,Fowler Curtis³,Greene Dina⁵⁶,Ralston James⁵⁶,Samadpour Mansour³,Sokurenko Evgeni¹^ORCID

Affiliation:

1. University of Washington, Seattle, Washington, USA

2. ID Genomics, Inc., Seattle, Washington, USA

3. IEH Laboratories and Consulting Group, Seattle, Washington, USA

4. ARMADA (The Antibiotic Resistance Monitoring, Analysis and Diagnostics Alliance), Seattle, Washington, USA

5. Kaiser Permanente Washington (KPWA), Seattle, Washington, USA

6. KPWA Research Institute, Seattle, Washington, USA

Abstract

We report that there is a recent global expansion of numerous independent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with mutation L452R in the receptor-binding domain (RBD) of the spike protein. The massive emergence of L452R variants was first linked to lineage B.1.427/B.1.429 (clade 21C) that has been spreading in California since November and December 2020, originally named CAL.20C and currently variant of interest epsilon.

Funder

ARMADA Foundation

ID Genomics

IEH Laboratories and Consulting Group

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.00921-21

Reference19 articles.