Phylogenetic Analysis of Viridans Group Streptococci Causing Endocarditis

Author:

Simmon Keith E.1,Hall Lori2,Woods Christopher W.23,Marco Francesc4,Miro Jose M.4,Cabell Christopher5,Hoen Bruno6,Marin Mercedes7,Utili Riccardo8,Giannitsioti Efthymia9,Doco-Lecompte Thanh10,Bradley Suzanne11,Mirrett Stanley3,Tambic Arjana12,Ryan Suzanne13,Gordon David14,Jones Phillip15,Korman Tony16,Wray Dannah17,Reller L. Barth3,Tripodi Marie-Francoise8,Plesiat Patrick6,Morris Arthur J.18,Lang Selwyn19,Murdoch David R.20,Petti Cathy A.121

Affiliation:

1. ARUP Laboratories, Salt Lake City, Utah

2. Duke University Medical Center

3. Veterans Administration Medical Center, Durham, North Carolina

4. Hospital Clinic Institut d'Investigacions Biomediques August Pi i Sunyer-University of Barcelona, Barcelona, Spain

5. Quintiles Transnational -

6. University Medical Center of Besançon, Besançon France

7. Hospital General Universitario Gregorio Maranon, Madrid, Spain

8. Second University of Naples, Naples, Italy

9. Attikon University General Hospital, Athens, Greece

10. CHU Nancy-Brabois, Nancy, France

11. Veterans Administration Medical Center, Ann Arbor, Michigan

12. University Hospital for Infectious Diseases, Zagreb, Croatia

13. South Eastern Sydney and Illawarra Area Health Service, Wollongong, Australia

14. Flinders Medical Centre, Adelaide, Australia

15. The University of New South Wales, Sydney, Australia

16. Southern Health, Clayton, Australia

17. Medical University of South Carolina, Charleston, South Carolina

18. Auckland City Hospital, Auckland, New Zealand

19. Middlemore Hospital, Auckland, New Zealand

20. University of Otago, Christchurch, New Zealand

21. Departments of Pathology and Medicine, University of Utah School of Medicine, Salt Lake City, Utah

Abstract

ABSTRACT Identification of viridans group streptococci (VGS) to the species level is difficult because VGS exchange genetic material. We performed multilocus DNA target sequencing to assess phylogenetic concordance of VGS for a well-defined clinical syndrome. The hierarchy of sequence data was often discordant, underscoring the importance of establishing biological relevance for finer phylogenetic distinctions.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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