Induction of B-Cell Lymphoma in BALB/c Nude Mice with an Ecotropic, B-Tropic Helper Virus Present in the Murine AIDS Virus Stock-Reference-Cited by-同舟云学术

Induction of B-Cell Lymphoma in BALB/c Nude Mice with an Ecotropic, B-Tropic Helper Virus Present in the Murine AIDS Virus Stock

Published:1999-02 Issue:2 Volume:73 Page:1640-1644
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Tayar Lamin¹,Higo Kyoko¹²,Kubo Yoshinao¹,Wang Yun³,Lu Ling-Min³,Zhang Fengmin¹,Iwatani Yasumasa¹,Wang Ling¹,Ono Takeshi¹,Maeda Michiyuki⁴,Sakai Hiroyuki¹,Ishimoto Akinori¹

Affiliation:

1. Laboratory of Gene Analysis, Department of Viral Oncology, Institute for Virus Research,1

2. Department of Pathology, School of Medicine, Fujita Health University, Toyoake 470-1192,2 Japan

3. Department of Pathology and Biology of Diseases, Graduate School of Medicine,3 and

4. Institute for Frontier Medical Science,4 Kyoto University, Sakyo-ku, Kyoto 606-8507, and

Abstract

ABSTRACT The pathogenicities of the murine AIDS (MAIDS) virus complex (LP-BM5) and ecotropic helper virus (BM5eco) isolated from the complex to BALB/c nude mice were studied to elucidate the possible role of replication-competent helper virus in inducing the monoclonal outgrowth of lymphoid cells. Neither LP-BM5 nor BM5eco was pathogenic in adult BALB/c nude mice. However, B-cell lymphoma developed with a very high frequency when either virus was inoculated into newborn BALB/c nude ( nu/nu ) mice. The cells from the B-cell lymphoma were easily transplanted into nude mice. These results suggested that ecotropic helper virus in the MAIDS virus complex plays an important role in inducing the monoclonal outgrowth of lymphoid cells under immunodeficient conditions caused by defective virus.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.73.2.1640-1644.1999

Reference22 articles.

1. Severe immunodeficiency disease induced by a defective murine leukaemia virus;Aziz D. C.;Nature,1989

2. Identification and mapping of a common proviral integration site Fli-1 in erythroleukemia cells induced by Friend murine leukemia virus;Ben-David Y.;Proc. Natl. Acad. Sci. USA,1990

3. Insertional inactivation of the p53 gene during Friend leukemia: a new strategy for identifying tumor suppressor genes;Ben-David Y.;New Biol.,1990

4. Defective virus is associated with induction of murine retrovirus-induced immunodeficiency syndrome;Chattopadhyay S. K.;Proc. Natl. Acad. Sci. USA,1989

5. Characteristics and contributions of defective, ecotropic, and mink cell focus-inducing viruses involved in a retrovirus-induced immunodeficiency syndrome of mice

Cited by 8 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The Role of Myeloid-Derived Suppressor Cells in Viral Infection;Viral Immunology;2017-03

2. Myeloid-derived suppressor cells in murine AIDS inhibit B-cell responses in part via soluble mediators including reactive oxygen and nitrogen species, and TGF-β;Virology;2016-12

3. Pathogenic risk of endogenous retrovirus infection in immunodeficient hosts;Virus Research;2008-03

4. Murine AIDS requires CD154/CD40L expression by the CD4 T cells that mediate retrovirus-induced disease: Is CD4 T cell receptor ligation needed?;Virology;2007-03

5. The Role of CD4 T Cells in the Pathogenesis of Murine AIDS;Journal of Virology;2006-06-15