Antibiotic-Induced Dysbiosis Predicts Mortality in an Animal Model of Clostridium difficile Infection-Reference-Cited by-同舟云学术

Antibiotic-Induced Dysbiosis Predicts Mortality in an Animal Model of Clostridium difficile Infection

Published:2018-10 Issue:10 Volume:62 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Burdet Charles¹²,Sayah-Jeanne Sakina³,Nguyen Thu Thuy¹,Hugon Perrine³,Sablier-Gallis Frédérique³,Saint-Lu Nathalie³,Corbel Tanguy³,Ferreira Stéphanie⁴,Pulse Mark⁵,Weiss William⁵,Andremont Antoine¹,Mentré France¹²,de Gunzburg Jean³

Affiliation:

1. INSERM and Paris Diderot University, IAME, UMR 1137, Paris, France

2. Department of Epidemiology, Biostatistic and Clinical Research, Bichat Hospital, Assistance Publique-Hopitaux de Paris, Paris, France

3. Da Volterra, Paris, France

4. GenoScreen, Lille, France

5. University of North Texas Health Science Center, Fort Worth, Texas, USA

Abstract

Antibiotic disruption of the intestinal microbiota favors colonization by Clostridium difficile . Using a charcoal-based adsorbent to decrease intestinal antibiotic concentrations, we studied the relationship between antibiotic concentrations in feces and the intensity of dysbiosis and quantified the link between this intensity and mortality.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00925-18

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