XAF1 Protects Host against Emerging RNA Viruses by Stabilizing IRF1-Dependent Antiviral Immunity-Reference-Cited by-同舟云学术

XAF1 Protects Host against Emerging RNA Viruses by Stabilizing IRF1-Dependent Antiviral Immunity

Published:2022-09-14 Issue:17 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Han Yu¹²³,Bai Xue⁴,Liu Siying²³,Zhu Jingfei²³,Zhang Fan²³,Xie Lifen²³,Liu Guodi²³,Jiang Xiaohui²³,Zhang Mingchao²³,Huang Yingkang²³,Wang Jingfeng²³,Li Dapei²³,Zhang Huiying²³,He Yuanqing²³,He Sudan²³,Xia Yu⁵,Xu Xiulong⁴^ORCID,Xu Feng¹,Ma Feng²³^ORCID

Affiliation:

1. Department of Infectious Diseases, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China

2. CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

3. Suzhou Institute of Systems Medicine, Suzhou, China

4. Institute of Comparative Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou, China

5. Suzhou Center for Disease Control and Prevention, Suzhou, China

Abstract

Rapid and robust induction of antiviral genes is essential for the host to clear the invaded viruses. In addition to the IRF3/7-IFN-I-STAT1 signaling axis, the XAF1-IRF1 positive feedback loop synergistically or independently drives the transcription of antiviral genes.

Funder

CAMS Innovation Fund for Medical Sciences

Suzhou Health talent project

People's Livehood Project of Suzhou Science and Technology Plan

MOST | National Key Research and Development Program of China

National Natural Science Foundation of China

Natural Science Foundation of Jiangsu Province

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link