IL-15 Superagonist N-803 Enhances IFN-γ Production of MAIT Cells in SIV <sup>+</sup> Macaques-Reference-Cited by-同舟云学术

IL-15 Superagonist N-803 Enhances IFN-γ Production of MAIT Cells in SIV ⁺ Macaques

Published:2022-10-20 Issue:10 Volume:90 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Ellis-Connell Amy L.¹,Balgeman Alexis J.¹,Kannal Nadean M.¹,Hansen Chaimson Karigynn¹,Batchenkova Anna¹,Safrit Jeffrey T.²,O’Connor Shelby L.¹³^ORCID

Affiliation:

1. Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA

2. ImmunityBio, Culver City, California, USA

3. Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, USA

Abstract

Mucosal associated invariant T (MAIT) cells are innate T cells that recognize bacterial metabolites and secrete cytokines and cytolytic enzymes to destroy infected target cells. This makes MAIT cells promising targets for immunotherapy to combat bacterial infections.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.00259-22

Reference69 articles.

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3. Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1

4. The biology and functional importance of MAIT cells

5. MR1 presents microbial vitamin B metabolites to MAIT cells

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