Affiliation:
1. Department of Pathology, University of Pittsburgh School of Medicine, Pennsylvania, USA.
Abstract
Lack of disease in long-term nonprogressors with human immunodeficiency virus type 1 (HIV-1) infection was strongly associated with very low copy numbers of HIV-1 DNA and RNA in peripheral blood mononuclear cells and plasma and the presence of high levels of anti-HIV-1 CD8+ memory cytotoxic T lymphocytes specific for Gag, Pol, and Env, compared with levels present in intermediate and advanced progressors. CD8+ memory cytotoxic T lymphocytes may have an important role in controlling HIV-1 replication and preventing disease in long-term nonprogressors.
Publisher
American Society for Microbiology
Subject
Virology,Insect Science,Immunology,Microbiology
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