The leader polypeptide of Theiler's virus is essential for neurovirulence but not for virus growth in BHK cells-Reference-Cited by-同舟云学术

The leader polypeptide of Theiler's virus is essential for neurovirulence but not for virus growth in BHK cells

Published:1995-09 Issue:9 Volume:69 Page:5544-5549
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Calenoff M A¹,Badshah C S¹,Dal Canto M C¹,Lipton H L¹,Rundell M K¹

Affiliation:

1. Department of Microbiology-Immunology, Northwestern University School of Medicine, Chicago, Illinois 60611, USA.

Abstract

A leader polypeptide of unknown function is encoded by cardioviruses, such as Theiler's murine encephalomyelitis virus. Although the deletion of this polypeptide has little effect on the growth of parental GDVII virus in baby hamster kidney (BHK) cells, the mutant virus is completely attenuated and fails to kill mice receiving intracerebral inoculations of high doses of the virus.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.69.9.5544-5549.1995

Reference36 articles.

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