Affiliation:
1. National Institute for Public Health and the Environment, RIVM, Bilthoven, The Netherlands
2. Erasmus Medical Center, Department of Virology, Rotterdam, The Netherlands
Abstract
ABSTRACT
The incidence of enterovirus 71 (EV71) infection has greatly increased in the Asian Pacific region since 1997. Several large outbreaks, caused by different subgenogroups of EV71, occurred with high rates of morbidity and a substantial number of deaths. In 2007, 58 cases of EV71 infection requiring hospitalization were reported in The Netherlands after a period of low endemicity of 21 years. These events triggered a study on the epidemiology of EV71 in The Netherlands. Genetic analysis of the VP1 capsid region of 199 EV71 isolates collected from 1963 to 2008 as part of enterovirus surveillance activities revealed a change in the prevailing subgenogroups over time. From 1963 to 1986 infections were caused by three different and successive lineages belonging to subgenogroup B (the novel lineage designated B0, as well as B1 and B2). In 1987, following a major epidemic the previous year, the B genogroup was replaced by genogroup C strains of lineages C1 and, later, C2. Analyses of the clinical data suggested that there were differences between infection with genogroup B and with genogroup C strains in terms of the age groups affected and the severity of illness. From comparative analysis with genomic data available in the public domain, we concluded that EV71 strain evolution shows a global pattern, which leads to the question of whether the recently emerged C4 lineage strains will also spread outside of Asia.
Publisher
American Society for Microbiology
Reference47 articles.
1. AbuBakar, S., I. C. Sam, J. Yusof, M. K. Lim, S. Misbah, N. MatRahim, and P. S. Hooi. 2009. Enterovirus 71 outbreak, Brunei. Emerg. Infect. Dis.15:79-82.
2. Molecular Epidemiology of Human Enterovirus 71 in the United Kingdom from 1998 to 2006
3. Bible, J. M., P. Pantelidis, P. K. Chan, and C. Y. Tong. 2007. Genetic evolution of enterovirus 71: epidemiological and pathological implications. Rev. Med. Virol. 17:371-379.
4. Molecular Epidemiology and Evolution of Enterovirus 71 Strains Isolated from 1970 to 1998
5. Cardosa, M. J., S. Krishnan, P. H. Tio, D. Perera, and S. C. Wong. 1999. Isolation of subgenus B adenovirus during a fatal outbreak of enterovirus 71-associated hand, foot, and mouth disease in Sibu, Sarawak. Lancet354:987-991.
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