Affiliation:
1. Mycology Research Laboratory, Veterans Administration Hospital, San Fernando, California 91342
2. Naval Biological Laboratory, University of California School of Public Health, Naval Supply Center, Oakland, California 94625
Abstract
In earlier reports, it was shown that mice and monkeys could be immunized against otherwise lethal challenge doses of
Coccidioides immitis
arthrospores. The vaccine was composed of Formalin-killed, in vitro grown, endosporulating spherules of
C. immitis
strain Silveira. In this study, mice were immunized as in the earlier work and then challenged intranasally with arthrospores from seven heterologous strains of
C. immitis
. Two of these strains were typical of the species, and five were atypical with respect to their cultural characteristics and morphology of microscopic structures. The vaccinated animals were well protected against challenge doses that were lethal to a majority of the control animals, regardless of the strain of fungus employed. The infection ratios among surviving vaccinated and control animals were comparable, but demonstrable lesions were generally smaller and less numerous in the vaccinated groups. It is suggested that these strains are at least immunogenically similar, although not necessarily identical, and that a vaccine prepared from a single strain of
C. immitis
would be practical for an immunization program.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Reference9 articles.
1. Effect of surface active agents on endosporulation of Coccidioides immitis in a chemically defined liquid medium;CONVERSE J. L.;J. Bacteriol.,1957
2. Studies on Coccidioides immitis: morphology and sporulation capacity of forty-seven strains;FRIEDMAN L., D.;J. Lab. Clin. Md.,1953
3. HUPPERT M. S. H. SUN AND J. W. BAILEY. 1967. Natural variability in Coccidioides immitis. Proc. Symp. Coccidioidomycosis 2nd p. 323-328.
4. Immunogenic properties of nondisrupted and disrupted spherules of Coccidioides immitis in mice;KONG Y. M.;Sabouraudia,1963
5. LEVINE H. B. J. M. COBB AND C. E. SM1TH. 1960. Immunity to coccidioidomycosis induced in VOL. 94 1967 RESPONSE OF MICE TO C( DCCIDIOIDAL CHALLENGE
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