In Vitro Activities of Omadacycline (PTK 0796) and Other Antimicrobial Agents against Human Mycoplasmas and Ureaplasmas-Reference-Cited by-同舟云学术

In Vitro Activities of Omadacycline (PTK 0796) and Other Antimicrobial Agents against Human Mycoplasmas and Ureaplasmas

Published:2016-12 Issue:12 Volume:60 Page:7502-7504
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Waites Ken B.¹,Crabb Donna M.¹,Liu Yang²,Duffy Lynn B.¹

Affiliation:

1. Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA

2. Institute of Antibiotics, Huashan Hospital, Institute of Biomedical Sciences, Fudan University, Shanghai, China

Abstract

ABSTRACT In vitro activities of omadacycline, a new aminomethylcycline, were determined for Mycoplasma and Ureaplasma spp. and compared with those of azithromycin, clindamycin, moxifloxacin, tetracycline, and doxycycline. All omadacycline MICs were <2 μg/ml. MIC 90 s were 0.063 μg/ml for Mycoplasma hominis , 0.25 μg/ml for Mycoplasma pneumoniae , and 2 μg/ml for Ureaplasma spp. Omadacycline had the lowest MIC 90 among all drugs tested against M. hominis . Omadacycline activity was not affected by macrolide, tetracycline, or fluoroquinolone resistance.

Funder

Paratek Pharmaceuticals, Boston, MA

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01734-16

Reference9 articles.

1. In VitroandIn VivoAntibacterial Activities of Omadacycline, a Novel Aminomethylcycline

2. Omadacycline: development of a novel aminomethylcycline antibiotic for treating drug-resistant bacterial infections

3. Mechanism of Action of the Novel Aminomethylcycline Antibiotic Omadacycline