Identification and Preliminary Characterization of Novel Type III Secreted Effector Proteins in Chlamydia trachomatis-Reference-Cited by-同舟云学术

Identification and Preliminary Characterization of Novel Type III Secreted Effector Proteins in Chlamydia trachomatis

Published:2023-07-18 Issue:7 Volume:91 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

McCaslin Paige N.¹,Andersen Shelby E.¹,Icardi Carolina M.¹,Faris Robert¹,Steiert Brianna¹,Smith Parker¹,Haider Jawad¹,Weber Mary M.¹^ORCID

Affiliation:

1. Department of Microbiology and Immunology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA

Abstract

Chlamydia trachomatis is an obligate intracellular pathogen that replicates in a host-derived vacuole termed the inclusion. Central to pathogenesis is a type III secretion system that translocates effector proteins into the host cell, which are predicted to play major roles in host cell invasion, nutrient acquisition, and immune evasion.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

University of Iowa Stead Family Scholars Program

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.00491-22

Reference55 articles.

1. Chlamydia cell biology and pathogenesis

2. CDC. 2020. Sexually transmitted disease surveillance 2020. CDC, Atlanta, GA.