Identification of Leptospiral Protein Antigens Recognized by WC1 + γδ T Cell Subsets as Target for Development of Recombinant Vaccines-Reference-Cited by-同舟云学术

Identification of Leptospiral Protein Antigens Recognized by WC1 + γδ T Cell Subsets as Target for Development of Recombinant Vaccines

Published:2022-01-25 Issue:1 Volume:90 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Teixeira Aline F.¹²^ORCID,Gillespie Alexandria¹,Yirsaw Alehegne¹,Britton Emily¹,Telfer Janice C.¹,Nascimento Ana Lucia Tabet Oller²^ORCID,Baldwin Cynthia L.¹

Affiliation:

1. Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, Massachusetts, USA

2. Laboratório de Desenvolvimento de Vacinas, Instituto Butantan, São Paulo, Brazil

Abstract

Pathogenic Leptospira species cause leptospirosis, a neglected zoonotic disease recognized as a global public health problem. It is also the cause of the most common cattle infection that results in major economic losses due to reproductive problems. γδ T cells play a role in the protective immune response in livestock species against Leptospira , while human γδ T cells also respond to Leptospira .

Funder

Fundação de Amparo à Pesquisa do Estado de São Paulo

UMASS | UMass Amherst | Center for Agriculture, Food and the Environment, University of Massachusetts Amherst

USDA | National Institute of Food and Agriculture

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00492-21

Reference68 articles.

1. Faine S, Adler B, Bolin C, Perolat P. 1999. Leptospira and leptospirosis. MediSci, Melbourne, Australia.