Proteomics Profiling Reveals Regulation of Immune Response to Salmonella enterica Serovar Typhimurium Infection in Mice

Author:

Huang He1,Even Zachary1,Wang Zhihan2,Li Ling1,Erickson Alyssa1,Golovko Mikhail3,Golovko Svetlana3,Darland Diane1ORCID,Mathur Ramkumar2,Wang Xusheng1ORCID

Affiliation:

1. Department of Biology, University of North Dakota, Grand Forks, North Dakota, USA

2. Department of Geriatrics, University of North Dakota, Grand Forks, North Dakota, USA

3. Department of Biomedical Sciences, University of North Dakota, Grand Forks, North Dakota, USA

Abstract

Regulation of the immune response to Salmonella enterica serovar Typhimurium ( S. Typhimurium) infection is a complex process, influenced by the interaction between genetic and environmental factors. Different inbred strains of mice exhibit distinct levels of resistance to S. Typhimurium infection, ranging from susceptible (e.g., C57BL/6J) to resistant (e.g., DBA/2J) strains. However, the underlying molecular mechanisms contributing to the host response remain elusive.

Funder

University of North Dakota

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

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