Construction and Characterization of the Mycobacterium tuberculosis sigE fadD26 Unmarked Double Mutant as a Vaccine Candidate

Author:

Hernandez-Pando Rogelio1,Shin Sung Jae2,Clark Simon3,Casonato Stefano4,Becerril-Zambrano Martin1,Kim Hongmin2,Boldrin Francesca4,Mata-Espinoza Dulce1,Provvedi Roberta5,Arbues Ainhoa6,Marquina-Castillo Brenda1,Cioetto Mazzabò Laura4,Barrios-Payan Jorge1,Martin Carlos6,Cho Sang-Nae2,Williams Ann3,Manganelli Riccardo4

Affiliation:

1. Experimental Pathology Section, Department of Pathology, National Institute of Medical Sciences and Nutrition Salvador Zubiràn, Mexico City, Mexico

2. Department of Microbiology, Institute for Immunology and Immunological Disease, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea

3. Public Health England, Microbiology Services, Porton Down, Salisbury, Wiltshire, United Kingdom

4. Department of Molecular Medicine, University of Padova, Padua, Italy

5. Department of Biology, University of Padova, Padua, Italy

6. Departamento de Microbiología, Facultad de Medicina, Universidad de Zaragoza, Zaragoza, Spain

Abstract

Despite the great increase in the understanding of the biology and pathogenesis of Mycobacterium tuberculosis achieved by the scientific community in recent decades, tuberculosis (TB) still represents one of the major threats to global human health.

Funder

Department of Health, UK

Science and Technology Institute of Mexico City

European Commission

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

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