Interleukin-10 (IL-10) Produced by Mutant Toxic Shock Syndrome Toxin 1 Vaccine-Induced Memory T Cells Downregulates IL-17 Production and Abrogates the Protective Effect against Staphylococcus aureus Infection-Reference-Cited by-同舟云学术

Interleukin-10 (IL-10) Produced by Mutant Toxic Shock Syndrome Toxin 1 Vaccine-Induced Memory T Cells Downregulates IL-17 Production and Abrogates the Protective Effect against Staphylococcus aureus Infection

Published:2019-10 Issue:10 Volume:87 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Narita Kouji¹²,Hu Dong-Liang¹³,Asano Krisana¹⁴,Nakane Akio¹⁴

Affiliation:

1. Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan

2. Institute for Animal Experimentation, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan

3. Laboratory of Zoonoses, Kitasato University School of Veterinary Medicine, Towada, Aomori, Japan

4. Department of Biopolymer and Health Science, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan

Abstract

Development of long-term memory is crucial for vaccine-induced adaptive immunity against infectious diseases such as Staphylococcus aureus infection. Toxic shock syndrome toxin 1 (TSST-1), one of the superantigens produced by S. aureus , is a possible vaccine candidate against infectious diseases caused by this pathogen.

Funder

MEXT | Japan Society for the Promotion of Science

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00494-19

Reference49 articles.

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2. Hospitalizations and Deaths Caused by Methicillin-ResistantStaphylococcus aureus, United States, 1999–2005

3. Development of a vaccine against Staphylococcus aureus