Affiliation:
1. College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China
2. State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, China
Abstract
Porcine reproductive and respiratory syndrome (PRRS), caused by PRRSV, causes significant worldwide economic losses in the pork industry. HOXA3 is generally considered to be an important molecule in the process of body development and cell differentiation. Here, we found that a novel transcription factor of the HO-1 gene, HOXA3, can negatively regulate the transcription of the HO-1 gene and play an important role in the suppression of IFN-I response by PRRSV.
Funder
China Agriculture Research System of MOF and MARA
Science Foundation for Distinguished Young Scholars of Shaanxi Province
Open Project of the State Key Laboratory of Veterinary Etiological Biology
Youth Innovation Team of Shaanxi Universities
Chinese Academy of Agricultural Science and Technology Innovation Project
MOE | Fundamental Research Funds for the Central Universities
National Natural Science Foundation of China
Publisher
American Society for Microbiology
Subject
Virology,Insect Science,Immunology,Microbiology
Cited by
18 articles.
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