In Vitro Activity against Staphylococcus aureus of a Novel Antimicrobial Agent, PRF-119, a Recombinant Chimeric Bacteriophage Endolysin-Reference-Cited by-同舟云学术

In Vitro Activity against Staphylococcus aureus of a Novel Antimicrobial Agent, PRF-119, a Recombinant Chimeric Bacteriophage Endolysin

Published:2011-09 Issue:9 Volume:55 Page:4416-4419
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Idelevich Evgeny A.¹,von Eiff Christof¹,Friedrich Alexander W.²,Iannelli Domenico³,Xia Guoqing⁴,Peters Georg¹,Peschel Andreas⁴,Wanninger Ingrid⁵⁶,Becker Karsten¹

Affiliation:

1. Institute of Medical Microbiology, University Hospital Münster, Münster, Germany

2. Institute of Hygiene, University Hospital Münster, Münster, Germany

3. School of Agriculture, University of Naples, Portici, Naples, Italy

4. Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen, Germany

5. Hyglos GmbH, Bernried, Germany

6. Present address: University of Regensburg, Faculty of Medicine, Regensburg, Germany.

Abstract

ABSTRACT Antistaphylococcal activity of the novel chimeric endolysin PRF-119 was evaluated with the microdilution method. The MIC 50 and MIC 90 of 398 methicillin-susceptible Staphylococcus aureus isolates were 0.098 μg/ml and 0.391 μg/ml, respectively (range, 0.024 to 0.780 μg/ml). Both the MIC 50 and MIC 90 values of 776 methicillin-resistant S. aureus isolates were 0.391 μg/ml (range, 0.024 to 1.563 μg/ml). All 192 clinical isolates of coagulase-negative staphylococci exhibited MIC values of >50 μg/ml. In conclusion, PRF-119 exhibited very good activity specifically against S. aureus .

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00217-11

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