Evolution of Subspecies of Francisella tularensis

Author:

Svensson Kerstin1,Larsson Pär12,Johansson Daniel1,Byström Mona1,Forsman Mats1,Johansson Anders13

Affiliation:

1. Department of NBC-Analysis, Swedish Defence Research Agency, SE-901 82 Umeå, Sweden

2. Department of Clinical Microbiology, Bacteriology

3. Department of Clinical Microbiology, Infectious Diseases, Umeå University, SE-901 85 Umeå, Sweden

Abstract

ABSTRACT Analysis of unidirectional genomic deletion events and single nucleotide variations suggested that the four subspecies of Francisella tularensis have evolved by vertical descent. The analysis indicated an evolutionary scenario where the highly virulent F. tularensis subsp. tularensis (type A) appeared before the less virulent F. tularensis subsp. holarctica (type B). Compared to their virulent progenitors, attenuated strains of F. tularensis exhibited specific unidirectional gene losses.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

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