Fleroxacin resistance in Escherichia coli-Reference-Cited by-同舟云学术

Fleroxacin resistance in Escherichia coli

Published:1989-02 Issue:2 Volume:33 Page:239-241
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Chapman J S¹,Bertasso A¹,Georgopapadakou N H¹

Affiliation:

1. Roche Research Center, Nutley, New Jersey 07110.

Abstract

Spontaneous fleroxacin-resistant mutants of Escherichia coli K-12 were isolated at a frequency of 10(-10) to 10(-11) mutants per CFU plated. All mutants exhibited quinolone-resistant replicative DNA biosynthesis, and 4 of 11 mutants also had decreased amounts of OmpF or OmpC porin. None of the mutants had changes solely in porin proteins.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.33.2.239

Reference13 articles.

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