Role of the High-Affinity Zinc Uptake znuABC System in Salmonella enterica Serovar Typhimurium Virulence-Reference-Cited by-同舟云学术

Role of the High-Affinity Zinc Uptake znuABC System in Salmonella enterica Serovar Typhimurium Virulence

Published:2002-08 Issue:8 Volume:70 Page:4721-4725
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Campoy Susana¹,Jara Mónica¹,Busquets Núria¹,Pérez de Rozas Ana M.²,Badiola Ignacio²,Barbé Jordi¹²

Affiliation:

1. Department of Genetics and Microbiology, Universitat Autònoma de Barcelona

2. Centre de Recerca en Sanitat Animal (CReSA), Universitat Autònoma de Barcelona Institut de Recerca i Tecnologia Agroalimentària (UAB-IRTA), Bellaterra 08193, Barcelona, Spain

Abstract

ABSTRACT The Salmonella enterica serovar Typhimurium znuABC genes encoding a high-affinity zinc uptake system and its regulatory zur gene have been cloned. Salmonella serovar Typhimurium zur and znuC knockout mutants have been constructed by marker exchange. The 50% lethal dose of the znuC mutant increased when either orally or intraperitoneally inoculated in BALB/c mice, while virulence of the zur mutant decreased only when mice were intraperitoneally challenged.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.70.8.4721-4725.2002

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