Mice That Are Congenic for the char2 Locus Are Susceptible to Malaria-Reference-Cited by-同舟云学术

Mice That Are Congenic for the char2 Locus Are Susceptible to Malaria

Published:2002-08 Issue:8 Volume:70 Page:4750-4753
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Burt Rachel A.¹,Marshall Vikki M.¹,Wagglen Jamie¹,Rodda Fleur R.¹,Senyschen Danielle¹,Baldwin Tracey M.¹,Buckingham Lynn A.¹,Foote Simon J.¹

Affiliation:

1. The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria 3050, Australia

Abstract

ABSTRACT A major advance has been made towards the positional cloning of char2 (a quantitative trait locus encoding resistance to Plasmodium chabaudi malaria). Mice congenic for the locus have been used to fine map the gene and to prove that char2 plays a significant role in the outcome of malarial infection, independently of other resistance loci.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.70.8.4750-4753.2002

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