Expression of Inducible Nitric Oxide Synthase in Skin Lesions of Patients with American Cutaneous Leishmaniasis-Reference-Cited by-同舟云学术

Expression of Inducible Nitric Oxide Synthase in Skin Lesions of Patients with American Cutaneous Leishmaniasis

Published:2002-08 Issue:8 Volume:70 Page:4638-4642
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Qadoumi Muna¹,Becker Inge²,Donhauser Norbert¹,Röllinghoff Martin¹,Bogdan Christian¹

Affiliation:

1. Institute of Clinical Microbiology, Immunology and Hygiene, University of Erlangen, Erlangen, Germany

2. Departamento de Medicina Experimental, Facultad de Medicina, Universidad Nacional Autonoma De Mexico, Mexico City, Mexico

Abstract

ABSTRACT Cytokine-inducible (or type 2) nitric oxide synthase (iNOS) is indispensable for the resolution of Leishmania major or Leishmania donovani infections in mice. In contrast, little is known about the expression and function of iNOS in human leishmaniasis. Here, we show by immunohistological analysis of skin biopsies from Mexican patients with local (LCL) or diffuse (DCL) cutaneous leishmaniasis that the expression of iNOS was most prominent in LCL lesions with small numbers of parasites whereas lesions with a high parasite burden (LCL or DCL) contained considerably fewer iNOS-positive cells. This is the first study to suggest an antileishmanial function of iNOS in human Leishmania infections in vivo.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.70.8.4638-4642.2002

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