Humanized NOD/SCID/IL2Rγ null Mice Transplanted with Hematopoietic Stem Cells under Nonmyeloablative Conditions Show Prolonged Life Spans and Allow Detailed Analysis of Human Immunodeficiency Virus Type 1 Pathogenesis-Reference-Cited by-同舟云学术

Humanized NOD/SCID/IL2Rγ null Mice Transplanted with Hematopoietic Stem Cells under Nonmyeloablative Conditions Show Prolonged Life Spans and Allow Detailed Analysis of Human Immunodeficiency Virus Type 1 Pathogenesis

Published:2007-12 Issue:23 Volume:81 Page:13259-13264
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Watanabe Satoru¹²,Ohta Shinrai³,Yajima Misako⁴,Terashima Kazuo⁵,Ito Mamoru⁶,Mugishima Hideo⁷,Fujiwara Shigeyoshi⁴,Shimizu Kazufumi²,Honda Mitsuo³,Shimizu Norio¹,Yamamoto Naoki³⁵

Affiliation:

1. Department of Virology, Division of Medical Science, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan

2. Open Research Center for Genome and Infectious Disease Control, Nihon University School of Medicine, 30-1 Oyaguchikami-chou, Itabashi-ku, Tokyo 173-8610, Japan

3. AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan

4. Department of Infectious Diseases, National Research Institute for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo 154-8567, Japan

5. Department of Molecular Virology, Graduate School of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan

6. Central Institute for Experimental Animals, 1430 Nogawa, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan

7. Department of Pediatrics and Child Health, Nihon University School of Medicine, 30-1 Oyaguchikami-chou, Itabashi-ku, Tokyo 173-8610, Japan

Abstract

ABSTRACT In a previous study, we demonstrated that humanized NOD/SCID/IL2Rγ null (hNOG) mice constructed with human hematopoietic stem cells (HSCs) allow efficient human immunodeficiency virus type 1 (HIV-1) infection. However, HIV-1 infection could be monitored for only 43 days in the animals due to their short life spans. By transplanting HSCs without any myeloablation methods, the mice successfully survived longer than 300 days with stable engraftment of human cells. The mice showed high viremia state for more than the 3 months examined, with systemic HIV-1 infection and gradual decrease of CD4 + T cells analogous to that in humans. These capacities of the hNOG mice are very attractive for modeling mechanisms of AIDS progression and therapeutic strategy.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01353-07

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