Parasite Genotype Is a Major Predictor of Mortality from Visceral Leishmaniasis

Author:

Grace Cooper Alastair1,Sousa Carvalho Kátia Silene2,Sousa Lima Mayara Ingrid13,Costa Silva Vladimir2,Reis-Cunha João Luís1,Brune Matthew J.1,Forrester Sarah1,Pedrozo e Silva de Azevedo Conceição de Maria4,Costa Dorcas Lamounier256,Speed Doug7,Mottram Jeremy C.1ORCID,Jeffares Daniel C.1ORCID,Costa Carlos H. N.25

Affiliation:

1. York Biomedical Research Institute, Department of Biology, University of York, York, United Kingdom

2. Department of Community Medicine and Institute of Tropical Diseases Natan Portela, Federal University of Piauí, Teresina, Brazil

3. Department of Biology, Postgraduate Programs in Health Sciences and Postgraduate Program in Health and Environment, Federal University of Maranhão, São Luís, Maranhão, Brazil

4. Department of Medicine and Postgraduate Program in Health Sciences, Federal University of Maranhão, São Luís, Maranhão, Brazil

5. Intelligence Center for Emerging and Neglected Diseases, Teresina, PI, Brazil

6. Mother Child Department, Federal University of Piauí, Teresina, PI, Brazil

7. Centre for Quantitative Genetics and Genomics, Aarhus University, Aarhus, Denmark

Abstract

Multiple factors contribute to the risk of mortality from visceral leishmaniasis (VL), including, patient genotype, comorbidities, and nutrition. Many of these factors are influenced by socioeconomic biases.

Funder

UKRI | Medical Research Council

Wellcome Trust

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Fundação de Amparo à Pesquisa e ao Desenvolvimento Científico e Tecnológico do Maranhão

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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