Mycobacterium tuberculosis Utilizes Host Histamine Receptor H1 to Modulate Reactive Oxygen Species Production and Phagosome Maturation via the p38MAPK-NOX2 Axis

Author:

Mo Siwei123,Guo Jiubiao4,Ye Taosheng5,Zhang Ximeng1,Zeng Jiang6,Xu Yuzhong7,Peng Bin1,Dai Youchao1,Xiao Wei1,Zhang Peize5,Deng Guofang5,Xu Dechang6,Long Xiaoru23,Cai Yi1ORCID,Chen Xinchun1ORCID

Affiliation:

1. Guangdong Provincial Key Laboratory of Regional Immunity and Diseases, Department of Pathogen Biology, School of Medicine, Shenzhen University, Shenzhen, China

2. Department of Respiratory Medicine, Children’s Hospital of Chongqing Medical University, Chongqing Key Laboratory of Pediatrics, Chongqing, China

3. National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, Children’s Hospital of Chongqing Medical University, Chongqing, China

4. College of Pharmacy, Shenzhen Technology University, Shenzhen, China

5. Pulmonary Diseases Department Two, National Clinical Research Center for Infectious Disease (Shenzhen), Guangdong Provincial Clinical Research Center for Infectious Diseases (Tuberculosis), Shenzhen Third People's Hospital, Southern University of Science and Technology, Shenzhen, China

6. The Fifth People's Hospital of Ganzhou, Ganzhou, Jiangxi Province, China

7. Department of Clinical Laboratory, Shenzhen Baoan Hospital, Shenzhen University, Shenzhen, China

Abstract

Once engulfed in macrophage phagosomes, M. tuberculosis adopts various strategies to take advantage of the host environment for its intracellular survival. Histamine is an organic nitrogen-containing compound that mediates a plethora of cellular processes via different receptors, but the crosstalk mechanism between M. tuberculosis and HRH1 in macrophages is not clear.

Funder

National Natural Science Foundation of China

Science and Technology Project of Shenzhen

Guangdong Key Laboratory of Regional Immunity and Diseases

Natural Science Foundation of Top Talent of SZTU

Natural Science Foundation of Chongqing

National Center for Clinical medicine of child health and disease

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Reference35 articles.

1. Latent Tuberculosis Infection

2. Microbial Pathogenesis of Mycobacterium tuberculosis: Dawn of a Discipline

3. The WHO Global Tuberculosis 2021 Report - not so good news and turning the tide back to end TB;Jeremiah C;Int J Infect Dis,2022

4. Co‐evolution of M ycobacterium tuberculosis and H omo sapiens

5. The immunological life cycle of tuberculosis

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1. Phagocytosis of Mycobacterium tuberculosis: A Narrative of the Uptaking and Survival;Phagocytosis - Main Key of Immune System;2023-08-02

2. Mycobacterium tuberculosis-macrophage interaction: Molecular updates;Frontiers in Cellular and Infection Microbiology;2023-03-03

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