Spleen Tyrosine Kinase Is a Critical Regulator of Neutrophil Responses to Candida Species

Author:

Negoro Paige E.1,Xu Shuying1,Dagher Zeina1,Hopke Alex23,Reedy Jennifer L.13,Feldman Michael B.43,Khan Nida S.13,Viens Adam L.1,Alexander Natalie J.1,Atallah Natalie J.1,Scherer Allison K.13,Dutko Richard A.1,Jeffery Jane1,Kernien John F.5,Fites J. Scott6,Nett Jeniel E.75ORCID,Klein Bruce S.765,Vyas Jatin M.13ORCID,Irimia Daniel23ORCID,Sykes David B.83,Mansour Michael K.13

Affiliation:

1. Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA

2. Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA

3. Harvard Medical School, Boston, Massachusetts, USA

4. Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston Massachusetts, USA

5. Department of Medicine, University of Wisconsin—Madison, Madison Wisconsin, USA

6. Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA

7. Department of Medical Microbiology and Immunology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA

8. Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA

Abstract

Neutrophils are recognized to represent significant immune cell mediators for the clearance and elimination of the human-pathogenic fungal pathogen Candida . The sensing of fungi by innate cells is performed, in part, through lectin receptor recognition of cell wall components and downstream cellular activation by signaling components, including spleen tyrosine kinase (Syk). While the essential role of Syk in macrophages and dendritic cells is clear, there remains uncertainty with respect to its contribution in neutrophils. In this study, we demonstrated that Syk is critical for multiple cellular functions in neutrophils responding to major human-pathogenic Candida species. These data not only demonstrate the vital nature of Syk with respect to the control of fungi by neutrophils but also warn of the potential infectious complications arising from the recent clinical development of novel Syk inhibitors for hematologic and autoimmune disorders.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3