Streptococcus agalactiae Induces Placental Macrophages To Release Extracellular Traps Loaded with Tissue Remodeling Enzymes via an Oxidative Burst-Dependent Mechanism

Author:

Doster Ryan S.1ORCID,Sutton Jessica A.2,Rogers Lisa M.1,Aronoff David M.1234,Gaddy Jennifer A.15ORCID

Affiliation:

1. Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA

2. Department of Microbiology and Immunology, Meharry Medical College, Nashville, Tennessee, USA

3. Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, Tennessee, USA

4. Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA

5. Department of Veterans Affairs, Tennessee Valley Healthcare Systems, Nashville, Tennessee, USA

Abstract

Streptococcus agalactiae , also known as group B Streptococcus (GBS), is a common pathogen during pregnancy where infection can result in chorioamnionitis, preterm premature rupture of membranes (PPROM), preterm labor, stillbirth, and neonatal sepsis. Mechanisms by which GBS infection results in adverse pregnancy outcomes are still incompletely understood. This study evaluated interactions between GBS and placental macrophages. The data demonstrate that in response to infection, placental macrophages release extracellular traps capable of killing GBS. Additionally, this work establishes that proteins associated with extracellular trap fibers include several matrix metalloproteinases that have been associated with chorioamnionitis. In the context of pregnancy, placental macrophage responses to bacterial infection might have beneficial and adverse consequences, including protective effects against bacterial invasion, but they may also release important mediators of membrane breakdown that could contribute to membrane rupture or preterm labor.

Funder

HHS | National Institutes of Health

March of Dimes Foundation

Vanderbilt University Medical Center

Department of Veterans Affairs Career Development Award

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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