The Burkholderia cenocepacia Type VI Secretion System Effector TecA Is a Virulence Factor in Mouse Models of Lung Infection-Reference-Cited by-同舟云学术

The Burkholderia cenocepacia Type VI Secretion System Effector TecA Is a Virulence Factor in Mouse Models of Lung Infection

Published:2021-10-26 Issue:5 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Loeven Nicole A.¹,Perault Andrew I.²,Cotter Peggy A.²,Hodges Craig A.³,Schwartzman Joseph D.¹,Hampton Thomas H.¹^ORCID,Bliska James B.¹^ORCID

Affiliation:

1. Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth College, Hanover, New Hampshire, USA

2. University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA

3. Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio, USA

Abstract

B. cenocepacia is often considered the most virulent species in the Bcc because of its close association with cepacia syndrome in addition to its capacity to cause chronic lung infections in CF patients (1). Prior to the current study, virulence factors of B. cenocepacia important for causing lethal disease had not been identified in a CF animal model of lung infection.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

HHS | NIH | National Heart, Lung, and Blood Institute

Cystic Fibrosis Foundation

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.02098-21

Reference54 articles.