Microbial Analysis of Umbilical Cord Blood Reveals Novel Pathogens Associated with Stillbirth and Early Preterm Birth

Author:

Vander Haar Emilie L.12,Wu Guojun3,Gyamfi-Bannerman Cynthia14,Thomas Charlene5,Wapner Ronald J.1,Reddy Uma M.1,Zhao Liping3,Silver Robert M.6,Goldenberg Robert L.1,Han Yiping W.1789

Affiliation:

1. Department of Obstetrics and Gynecology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York, USA

2. Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, New York, USA

3. Department of Biochemistry and Microbiology, School of Environmental and Biological Sciences and Center for Microbiome, Nutrition, and Health, New Jersey Institute for Food, Nutrition, and Health, Rutgers, The State University of New Jersey, New Brunswick, New Jersey, USA

4. Department of Obstetrics, Gynecology, and Reproductive Sciences, UC San Diego, La Jolla, California, USA

5. Division of Biostatistics, Department of Population Health Sciences, Weill Cornell Medicine, New York, New York, USA

6. Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, Utah, USA

7. Section of Oral, Diagnostics and Rehabilitation Sciences, College of Dental Medicine, Columbia University Irving Medical Center, New York, New York, USA

8. Department of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York, USA

9. Institute of Human Nutrition, Columbia University Irving Medical Center, New York, New York, USA

Abstract

Stillbirth accounts for half of all perinatal mortality, but the underlying cause of a substantial portion of all cases remains elusive. We examined the umbilical cord blood microbiome in stillbirths ( n  = 60) and live births ( n  = 176) and discovered that the bacterial prevalence and abundance were significantly higher in stillbirths than live births.

Funder

NIDCR

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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