Noncanonical Translation Initiation Comes of Age

Author:

Babitzke Paul1ORCID,O'Connor Michael2

Affiliation:

1. Department of Biochemistry and Molecular Biology, Center for RNA Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, USA

2. School of Biological Sciences, University of Missouri—Kansas City, Kansas City, Missouri, USA

Abstract

ABSTRACT The canonical translation initiation mechanism involves base pairing between the mRNA and 16S rRNA. However, a variety of identified mechanisms deviate from this conventional route. Beck and Janssen (J Bacteriol 199:e00091-17, 2017, https://doi.org/10.1128/JB.00091-17 ) have recently described another noncanonical mode of translation initiation. Here, we describe how this process differs from previously reported mechanisms, with the hope that it will foster increased awareness of the diversity of regulatory mechanisms that await discovery.

Funder

Charles E. Kaufman Foundation of The Pittsburgh Foundation

School of Biological Sciences, University of Missouri—Kansas City

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

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