Hepatitis B Virus: Advances in Prevention, Diagnosis, and Therapy

Author:

Nguyen Mindie H.1,Wong Grace2,Gane Edward34,Kao Jia-Horng567,Dusheiko Geoffrey8

Affiliation:

1. Division of Gastroenterology and Hepatology, Stanford University Medical Center, Palo Alto, California, USA

2. Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong

3. New Zealand Liver Transplant Unit, Auckland City Hospital, Auckland, New Zealand

4. Department of Medicine, University of Auckland, Auckland, New Zealand

5. Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan

6. Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan

7. Hepatitis Research Center, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan

8. UCL Medical School, Kings College Hospital, London, United Kingdom

Abstract

Currently, despite the use of a preventive vaccine for several decades as well as the use of effective and well-tolerated viral suppressive medications since 1998, approximately 250 million people remain infected with the virus that causes hepatitis B worldwide. Hepatitis C virus (HCV) and hepatitis B virus (HBV) are the leading causes of liver cancer and overall mortality globally, surpassing malaria and tuberculosis. Linkage to care is estimated to be very poor both in developing countries and in high-income countries, such as the United States, countries in Western Europe, and Japan.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Microbiology (medical),Public Health, Environmental and Occupational Health,General Immunology and Microbiology,Epidemiology

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