Affiliation:
1. Radiation Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892.
Abstract
Only a few of the genes involved in DNA repair in mammalian cells have been isolated, and induction of a DNA repair gene in response to DNA damage has not yet been established. DNA polymerase beta (beta-polymerase) appears to have a synthetic role in DNA repair after certain types of DNA damage. Here we show that the level of beta-polymerase mRNA is increased in CHO cells after treatment with several DNA-damaging agents.
Publisher
American Society for Microbiology
Subject
Cell Biology,Molecular Biology