Affiliation:
1. Infectious Disease Unit, Massachusetts General Hospital, Boston 02114, USA.
Abstract
PIC 024-4 and PRO 2000 are naphthalene sulfonate polymers that bind to CD4 with nanomolar affinity and block binding of gp120. Both have activity against human immunodeficiency virus type 1 in H9 cells, peripheral blood mononuclear cells, and primary monocyte/macrophages, are synergistic with zidovudine, and do not inhibit tetanus toxoid-stimulated T-cell proliferation at anti-human immunodeficiency virus type 1 concentrations.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference23 articles.
1. A soluble multimeric recombinant CD2 protein identifies CD48 as a low affinity ligand for human CD2: divergence of CD2 ligands during the evolution of humans and mice;Arulanandam A. R. N.;J. Exp. Med.,1993
2. Dextran sulfate blocks antibody binding to the principal neutralizing domain of human immunodeficiency virus type 1 without interfering with gp120-CD4 interactions;Callahan L. N.;J. Virol.,1991
3. Chou J. H. and T.-C. Chou. 1989. Dose-effect analysis with microcomputers: quantitation of ED50 LD50 synergism antagonism low-dose risk receptor-ligand binding and enzyme kinetics: a computer software for IBM-PC and manual. Biosoft Cambridge Mass.
4. Chou T.-C. 1991. The median-effect principle and the combination index for quantitation of synergism and antagonism p. 61-102. In T.-C. Chou and D. C. Rideout (ed.) Synergism and antagonism in chemotherapy. Academic Press New York.
5. Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors;Chou T.;Adv. Enzyme. Regul.,1984
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