Elevated Concentrations of Eotaxin and Interleukin-5 in Human Neurocysticercosis-Reference-Cited by-同舟云学术

Elevated Concentrations of Eotaxin and Interleukin-5 in Human Neurocysticercosis

Published:1998-09 Issue:9 Volume:66 Page:4522-4525
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Evans Carlton A. W.¹,Garcia Hector H.²³,Hartnell Adele⁴,Gilman Robert H.²⁵⁶,Jose Peter J.⁴,Martinez Manuel³,Remick Daniel G.⁷,Williams Timothy J.⁴,Friedland Jon S.¹

Affiliation:

1. Department of Infectious Diseases, Imperial College School of Medicine, Hammersmith Hospital,1 and

2. Department of Microbiology and Pathology, Universidad Cayetano Heredia,2

3. Instituto National de Ciencias Neurologicas,3 and

4. Department of Applied Pharmacology, Imperial College School of Medicine, National Heart and Lung Institute,4 London, United Kingdom;

5. AB Prisma,6 Lima, Peru;

6. Department of International Health, Johns Hopkins School of Hygiene and Public Health, Baltimore, Maryland5; and

7. Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan7

Abstract

ABSTRACT Symptomatic neurocysticercosis, a major cause of epilepsy worldwide, results from inflammation around Taenia solium larvae, but the mechanisms are unknown. Eotaxin, not previously reported in cases of human infection, and interleukin-5 (IL-5) but not IL-8 concentrations were elevated in patient serum, and IL-5 levels were also elevated in cerebrospinal fluid (CSF). Eosinophil-selective mediators may be involved in the pathogenesis of cysticercosis. IL-6 concentrations were also elevated in patient CSF, possibly indicative of an acute-phase response.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.66.9.4522-4525.1998

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