Protective Effect of Vaccination with a Combination of Recombinant Surface Antigen 1 and Interleukin-12 against Toxoplasmosis in Mice-Reference-Cited by-同舟云学术

Protective Effect of Vaccination with a Combination of Recombinant Surface Antigen 1 and Interleukin-12 against Toxoplasmosis in Mice

Published:1998-09 Issue:9 Volume:66 Page:4503-4506
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Letscher-Bru Valerie¹,Villard Odile¹,Risse Bernhard²,Zauke Michael²,Klein Jean-Paul³,Kien Truong T.¹

Affiliation:

1. Institut de Parasitologie et de Pathologie Tropicale, Inserm U392, Faculté de Médecine,1 and

2. Roche Diagnostics, Basel, Switzerland2

3. Faculté de Pharmacie,3 67000 Strasbourg, France, and

Abstract

ABSTRACT We studied the immune response induced in mice by recombinant Toxoplasma gondii surface antigen 1 (rSAG1) protein, alone or combined with interleukin-12 (IL-12) as an adjuvant, and the protective effect against toxoplasmosis. Immunization with rSAG1 alone induced a specific humoral type 2 immunity and did not protect the animals from infection. In contrast, immunization with rSAG1 plus IL-12 redirected humoral and cellular immunity toward a type 1 pattern and reduced the brain parasite load by 40%.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.66.9.4503-4506.1998

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