Cloned Lines of Plasmodium berghei ANKA Differ in Their Abilities To Induce Experimental Cerebral Malaria-Reference-Cited by-同舟云学术

Cloned Lines of Plasmodium berghei ANKA Differ in Their Abilities To Induce Experimental Cerebral Malaria

Published:1998-09 Issue:9 Volume:66 Page:4093-4099
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Amani Véronique¹,Boubou Mariama Idrissa¹,Pied Sylviane¹,Marussig Myriam¹,Walliker David²,Mazier Dominique¹,Rénia Laurent¹

Affiliation:

1. INSERM U313 and Department of Parasitology, Groupe Hospitalier Pitié-Salpêtrière, 75013 Paris, France,1 and

2. Department of Genetics, Institute of Cell, Animal and Population, University of Edinburgh, Edinburgh EH9 3JN, United Kingdom2

Abstract

ABSTRACT Infection with Plasmodium berghei ANKA is usually lethal. The parasite causes in some mouse strains a neurovascular syndrome, experimental cerebral malaria (ECM), involving immunopathological reactions. The effects on the development of ECM of the mouse genetic background have been clearly demonstrated, but nothing is known about the effects of the clonal diversity of the parasite. We showed that various cloned lines derived from a polyclonal line of P. berghei ANKA caused ECM but that the extent of ECM induction was dependent on the amount of inoculum. Subtle differences in ECM characteristics (survival time and hypothermia) were also observed. We also confirmed, using the 1.49L cloned line, that the mouse genetic background strongly affects ECM.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.66.9.4093-4099.1998

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