Extreme Sensitivity of Staphylococcal Enterotoxin B and C Production to Inhibition by Cerulenin

Author:

Altenbern Robert A.1

Affiliation:

1. U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland 21701

Abstract

Production of staphylococcal enterotoxins B and C was completely inhibited by concentrations of cerulenin (4 μg/ml and 2 μg/ml, respectively) that did not affect either growth rate or final growth density. Type A toxin formation was not similarly inhibited.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference7 articles.

1. On the nature of albumin-promoted coagulase release by Staphylococcus aureus;Altenbern R. A.;J. Infect. Dis.,1966

2. Enterotoxin B formation by fermentation mutants ofStaphylococcus aureus;Altenbern R. A.;Can. J. Microbiol.,1976

3. Induction of mutants ofStaphylococcus aureus 100 with increased ability to produce enterotoxin A;Friedman M. E.;J. Bacteriol.,1971

4. Importance of membrane fluidity in the induction of alkaline phosphatase, a periplasmic enzyme, in Escherichia coli;Kimura K.;Biochem. Biophys. Res. Commun.,1976

5. Lampen J. 0. 1974. Movement of extracellular enzymes across cell membranes p. 351-374. In M. A. Sleigh and D. H. Jennings (ed.) Transport at the cellular level. Cambridge University Press Cambridge England.

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