Temporal Proteomic Analysis of BK Polyomavirus Infection Reveals Virus-Induced G 2 Arrest and Highly Effective Evasion of Innate Immune Sensing

Author:

Caller Laura G.1,Davies Colin T. R.2,Antrobus Robin2,Lehner Paul J.2ORCID,Weekes Michael P.2ORCID,Crump Colin M.1ORCID

Affiliation:

1. Division of Virology, Department of Pathology, University of Cambridge, Cambridge, United Kingdom

2. Cambridge Institute for Medical Research, Addenbrooke’s Hospital, Cambridge, United Kingdom

Abstract

BK polyomavirus can cause serious problems in immune-suppressed patients, in particular, kidney transplant recipients who can develop polyomavirus-associated kidney disease. In this work, we have used advanced proteomics techniques to determine the changes to protein expression caused by infection of two independent primary cell types of the human urinary tract (kidney and bladder) throughout the replication cycle of this virus. Our findings have uncovered new details of a specific form of cell cycle arrest caused by this virus, and, importantly, we have identified that this virus has a remarkable ability to evade detection by host cell defense systems. In addition, our data provide an important resource for the future study of kidney epithelial cells and their infection by urinary tract pathogens.

Funder

Wellcome Trust

Issac Newton Trust

RCUK | Biotechnology and Biological Sciences Research Council

RCUK | Medical Research Council

Evelyn Trust

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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