Landscape of New Nuclease-Containing Antiphage Systems in Escherichia coli and the Counterdefense Roles of Bacteriophage T4 Genome Modifications-Reference-Cited by-同舟云学术

Landscape of New Nuclease-Containing Antiphage Systems in Escherichia coli and the Counterdefense Roles of Bacteriophage T4 Genome Modifications

Published:2023-06-29 Issue:6 Volume:97 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Wang Shuangshuang¹²³,Sun Erchao¹²³,Liu Yuepeng¹²³,Yin Baoqi¹²³,Zhang Xueqi¹²³,Li Mengling¹²³,Huang Qi¹²,Tan Chen¹²³^ORCID,Qian Ping¹²^ORCID,Rao Venigalla B.⁴,Tao Pan¹²³^ORCID

Affiliation:

1. State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei, China

2. Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agricultural University, Wuhan, Hubei, China

3. Hubei Hongshan Lab, Wuhan, Hubei, China

4. Bacteriophage Medical Research Center, Department of Biology, The Catholic University of America, Washington, DC, USA

Abstract

Cleavage of foreign DNA is a well-known mechanism used by bacteria to protect themselves from phage infections. Two well-known bacterial defense systems, R-M and CRISPR-Cas, both contain nucleases that cleave the phage genomes through specific mechanisms.

Funder

MOST | National Natural Science Foundation of China

MOE | Fundamental Research Funds for the Central Universities

Natural Science Foundation of Hubei Province

Earmark fund

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00599-23

Reference43 articles.