Biofilm Formation by Gram-Negative Bacteria on Central Venous Catheter Connectors: Effect of Conditioning Films in a Laboratory Model

Author:

Murga R.1,Miller J. M.1,Donlan R. M.1

Affiliation:

1. Biofilm Research Laboratory, Division of Healthcare Quality Promotion, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia

Abstract

ABSTRACT Human blood components have been shown to enhance biofilm formation by gram-positive bacteria. We investigated the effect of human blood on biofilm formation on the inner lumen of needleless central venous catheter connectors by several gram-negative bacteria, specifically Enterobacter cloacae, Pseudomonas aeruginosa , and Pantoea agglomerans . Results suggest that a conditioning film of blood components promotes biofilm formation by these organisms in an in vitro system.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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