Fulminant Japanese Spotted Fever Associated with Hypercytokinemia-Reference-Cited by-同舟云学术

Fulminant Japanese Spotted Fever Associated with Hypercytokinemia

Published:2001-06 Issue:6 Volume:39 Page:2341-2343
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Iwasaki Hiromichi¹,Mahara Fumihiko²,Takada Nobuhiro³,Fujita Hiromi⁴,Ueda Takanori⁵

Affiliation:

1. Division of Transfusion Medicine,1

2. Fukui Medical University, Fukui, Mahara Hospital, Tokushima,2and

3. Department of Immunology and Medical Zoology,3 and

4. Ohara Research Laboratory, Ohara General Hospital, Fukushima,4 Japan

5. First Department of Internal Medicine,5

Abstract

ABSTRACT We report a patient with Japanese spotted fever caused by Rickettsia japonica who developed shock associated with hypercytokinemia. Elevated levels of cytokines (macrophage colony-stimulating factor, interleukin 1 beta, interleukin 10, and gamma interferon) decreased rapidly after a combination treatment using an antibiotic (minocycline hydrochloride [MINO]) and methylprednisolone; however, tumor necrosis factor alpha levels were increased. The patient's fever relapsed and was resolved only after the addition of ciprofloxacin hydrochloride. The administration of new quinolones alone may be another useful form of treatment to eradicate R. japonica even if the symptoms of hypercytokinemia appear to improve with the administration of MINO and methylprednisolone.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.39.6.2341-2343.2001

Reference11 articles.

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5. Increased levels of macrophage colony-stimulating factor, gamma interferon, and tumor necrosis factor alpha in sera of patients with Orientia tsutsugamushi infection

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