Staphylococcus lugdunensis Uses the Agr Regulatory System to Resist Killing by Host Innate Immune Effectors-Reference-Cited by-同舟云学术

Staphylococcus lugdunensis Uses the Agr Regulatory System to Resist Killing by Host Innate Immune Effectors

Published:2022-10-20 Issue:10 Volume:90 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Chin Denny¹,Flannagan Ronald S.¹^ORCID,Tuffs Stephen W.¹^ORCID,Chan Jeremy K.¹,McCormick John K.¹,Heinrichs David E.¹^ORCID

Affiliation:

1. Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada

Abstract

Coagulase-negative staphylococci (CoNS) are frequently commensal bacteria that rarely cause disease in mammals. Staphylococcus lugdunensis is an exceptional CoNS that causes disease in humans similar to virulent Staphylococcus aureus , but the factors that enhance the virulence of this bacterium remain ill defined. Here, we used random transposon insertion mutagenesis to identify the agr quorum sensing system as a regulator of hemolysins in S. lugdunensis .

Funder

Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada

Gouvernement du Canada | Canadian Institutes of Health Research

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.00099-22

Reference69 articles.

1. Is Staphylococcus lugdunensis Significant in Clinical Samples?

2. Staphylococcus lugdunensis: a Skin Commensal with Invasive Pathogenic Potential