Specific Binding to Differentially Expressed Human Carcinoembryonic Antigen-Related Cell Adhesion Molecules Determines the Outcome of Neisseria gonorrhoeae Infections along the Female Reproductive Tract-Reference-Cited by-同舟云学术

Specific Binding to Differentially Expressed Human Carcinoembryonic Antigen-Related Cell Adhesion Molecules Determines the Outcome of Neisseria gonorrhoeae Infections along the Female Reproductive Tract

Published:2018-08 Issue:8 Volume:86 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Islam Epshita A.¹,Anipindi Varun C.²,Francis Ian³,Shaik-Dasthagirisaheb Yazdan³,Xu Stacey¹,Leung Nelly¹,Sintsova Anna¹,Amin Mohsen¹,Kaushic Charu²,Wetzler Lee M.³,Gray-Owen Scott D.¹^ORCID

Affiliation:

1. Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

2. Department of Pathology and Molecular Medicine, McMaster Immunology Research Center, Michael DeGroote Centre for Learning and Discovery, McMaster University, Hamilton, Ontario, Canada

3. Section of Infectious Diseases, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA

Abstract

The gonococcal Opa proteins are an antigenically variable family of surface adhesins that bind human carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), CEACAM3, CEACAM5, and/or CEACAM6, cell surface glycoproteins that are differentially expressed on a broad spectrum of human cells and tissues. While they are presumed to be important for infection, the significance of various Opa-CEACAM-mediated cellular interactions in the context of the genital tract has remained unclear.

Funder

HHS | National Institutes of Health

Gouvernement du Canada | Canadian Institutes of Health Research

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00092-18

Reference49 articles.

1. CD66 carcinoembryonic antigens mediate interactions between Opa-expressing Neisseria gonorrhoeae and human polymorphonuclear phagocytes

2. Human-Like Immune Responses in CD46 Transgenic Mice