A Nonlethal Murine Flame Burn Model Leads to a Transient Reduction in Host Defenses and Enhanced Susceptibility to Lethal Pseudomonas aeruginosa Infection-Reference-Cited by-同舟云学术

A Nonlethal Murine Flame Burn Model Leads to a Transient Reduction in Host Defenses and Enhanced Susceptibility to Lethal Pseudomonas aeruginosa Infection

Published:2021-09-16 Issue:10 Volume:89 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Brammer Jerod¹²^ORCID,Choi Myeongjin¹,Baliban Scott M.¹,Kambouris Adrienne R.¹²,Fiskum Gary³,Chao Wei³,Lopez Kerri³⁴,Miller Catriona⁵,Al-Abed Yousef⁶,Vogel Stefanie N.²,Simon Raphael¹,Cross Alan S.¹

Affiliation:

1. Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA

2. Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA

3. Translational Research Program, Department of Anesthesiology & Center for Shock, Trauma and Anesthesiology Research, University of Maryland School of Medicine, Baltimore, Maryland, USA

4. Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA

5. Enroute Care Division, Department of Aeromedical Research, USAF School of Aerospace Medicine, Wright Patterson AFB, Dayton, Ohio, USA

6. Department of Biomedical Science, The Feinstein Institute for Medical Research, Manhasset, New York, USA

Abstract

Of the 486,000 burn injuries that required medical treatment in the United States in 2016, 40,000 people were hospitalized, with >3,000 fatalities. After burn injury, humans are at increased risk of sepsis and mortality from infections caused by Pseudomonas aeruginosa , an opportunistic pathogen.

Funder

DOD | U.S. Air Force

NIH

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00091-21

Reference42 articles.

1. ASTM International. 1997. Standard guide for heated systems surface conditions that produce contact burn injuries. ASTM International, West Conshohocken, PA.

2. The biology of burn injury

3. Burn injury

4. Infection in Burns

5. Sepsis in the burn patient: a different problem than sepsis in the general population

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5. A Nonlethal Full-Thickness Flame Burn Produces a Seroma Beneath the Forming Eschar, Thereby Promoting Pseudomonas aeruginosa Sepsis in Mice;Journal of Burn Care & Research;2021-11-05