The Endoribonuclease RNase E Coordinates Expression of mRNAs and Small Regulatory RNAs and Is Critical for the Virulence of Brucella abortus-Reference-Cited by-同舟云学术

The Endoribonuclease RNase E Coordinates Expression of mRNAs and Small Regulatory RNAs and Is Critical for the Virulence of Brucella abortus

Published:2020-09-23 Issue:20 Volume:202 Page:
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Sheehan Lauren M.¹,Budnick James A.¹,Fyffe-Blair Jaquille¹,King Kellie A.¹,Settlage Robert E.²^ORCID,Caswell Clayton C.¹^ORCID

Affiliation:

1. Center for One Health Research, Virginia-Maryland College of Veterinary Medicine, Blacksburg, Virginia, USA

2. Advanced Research Computing, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA

Abstract

Brucellosis is a debilitating disease of humans and animals globally, and there is currently no vaccine to combat human infection by Brucella spp. Moreover, effective antibiotic treatment in humans is extremely difficult and can lead to disease relapse. Therefore, it is imperative that systems and pathways be identified and characterized in the brucellae so new vaccines and therapies can be generated. In this study, we describe the impact of the endoribonuclease RNase E on the control of mRNA and small regulatory RNA (sRNA) levels in B. abortus , as well as the importance of RNase E for the full virulence of B. abortus . This work greatly enhances our understanding of ribonucleases in the biology and pathogenesis of Brucella spp.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

American Heart Association

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.00240-20

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