Mutation in the DNA Gyrase A Gene of Escherichia coli That Expands the Quinolone Resistance-Determining Region-Reference-Cited by-同舟云学术

Mutation in the DNA Gyrase A Gene of Escherichia coli That Expands the Quinolone Resistance-Determining Region

Published:2001-08 Issue:8 Volume:45 Page:2378-2380
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Friedman S. Marvin¹,Lu Tao²,Drlica Karl²

Affiliation:

1. Department of Biological Sciences, Hunter College of The City University of New York, New York, New York 10021,1 and

2. Public Health Research Institute, New York, New York 100162

Abstract

ABSTRACT In three Escherichia coli mutants, a change (Ala-51 to Val) in the gyrase A protein outside the standard quinolone resistance-determining region (QRDR) lowered the level of quinolone susceptibility more than changes at amino acids 67, 82, 84, and 106 did. Revision of the QRDR to include amino acid 51 is indicated.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.45.8.2378-2380.2001

Reference22 articles.

1. Roles of gyrA Mutations in Resistance of Clinical Isolates and In Vitro Mutants of Bacteroides fragilis to the New Fluoroquinolone Trovafloxacin

2. Thermotolerant nalidixic acid-resistant mutants of Escherichia coli.;Friedman S. M.;Curr. Microbiol.,1991

3. DNA supercoiling in a thermotolerant mutant of Escherichia coli.;Friedman S. M.;Mol. Gen. Genet.,1995

4. Mechanisms and Frequency of Resistance to Premafloxacin in Staphylococcus aureus : Novel Mutations Suggest Novel Drug-Target Interactions

5. Jendrisak J. Young R. Engel J. Guide to molecular cloning techniques Berger S. Kimmel A. 1978 359 371 Academic Press Inc. New York N.Y

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